Phenotype Image Detail

Image

Caption

Hematoxylin and eosin-stained coronal sections of E11.5 wild type (+/+) and Por^tm1Cbk/Por^tm1Cbk (-/-) embryos. se, surface ectoderm; ne, neuroepithelium; e, eye. A, wild-type embryo, magnification x2.5. B, mutant embryo, magnification x2.5. The asterisk indicates the neural tube region infiltrated by blood cells, which is magnified in panel C. Filled triangle, the fronto-nasal region containing apoptotic cells, which is magnified in panel D. C, magnification (x20) of the region indicated by the asterisk in panel B. D, magnification (x100) of the region indicated by the filled triangle in panel B, with arrowheads indicating cells with pyknotic nuclei.

Copyright

This image is from Shen AL, J Biol Chem 2002 Feb 22;277(8):6536-41 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:74666

Associated Alleles

Symbol	Name
Por^tm1Cbk	cytochrome p450 oxidoreductase; targeted mutation 1, Charles B Kasper

Associated Genotypes

Allelic Composition	Genetic Background
Por^tm1Cbk/Por^tm1Cbk	involves: 129S1/Sv * 129X1/SvJ * C57BL/6