Phenotype Image Detail

Image

Caption

A: Morphology of E7.5 wild-type (+/+) and Prkar1a^tm1Gsm/Prkar1a^tm1Gsm (-/-) embryos. Mutant embryos are smaller than wild-type littermates but have a well formed A-P axis, including head-folds, node and allantois. B: Morphology of E8.5 wild-type and mutant embryos. Mutant embryos show severe growth retardation and developmental delay resembling presomite head-fold stage embryos. The cardiogenic plate is present but no heart tube had formed. C: Morphology of E9.5 wild-type and mutant embryos. E9.5 mutant embryos are severely growth-retarded, have failed to form a contractile heart tube, and have not initiated the turning process. D: Comparison of an E9.5 mutant embryo with wild-type embryos from several stages of development. Mutant embryos at E9.5 resemble E8.0 wild-type embryos. Although mutants are approximately the same size as E8.0 wild-type embryos, mutants differ in that they have more somites, an allantois that is thickened at the base, a more radical entry of the foregut, and bilateral cardiocytes that have failed to fuse ventrally to form the heart. Scale bars: A-D, 500 um. Abbreviations: al, allantois; cp, cardiogenic plate; fg, foregut; hp, head process; ht, heart; nd, node; tr, trunk; ys, yolk sac.

Copyright

This image is from Amieux PS, J Biol Chem 2002 Jul 26;277(30):27294-304 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78010

Associated Alleles

Symbol	Name
Prkar1a^tm1Gsm	protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight

Associated Genotypes

Allelic Composition	Genetic Background
Prkar1a^tm1Gsm/Prkar1a^tm1Gsm	involves: 129X1/SvJ * C57BL/6