Phenotype Image Detail

Image

Caption

Lungs of newborn Slc27a4^tm1Wsr/Slc27a4^tm1Wsr (Fatp4 -/-) mice and wild-type (Fatp4+/+) control littermates. A: Severe atelectasis of the lung in mutant mice. Mutant lungs, stained with hematoxylin and eosin, exhibit a reduced extension of the alveolae and an increase in width of the cellular alveolar septae. Bars, 100 um. B: Ultrastructural analysis of type II alveolar cells and alveolar surfactant in mutant mice (ruthenium tetroxide fixation). Lung tissue was obtained immediately after birth and prepared for EM. Extracellular forms of surfactant, which can be detected in both wild-type and mutant mice without distinction between genotypes, are marked by arrows. Bars, 5 um.

Copyright

This image is from Herrmann T, J Cell Biol 2003 Jun 23;161(6):1105-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:84096

Associated Alleles

Symbol	Name
Slc27a4^tm1Wsr	solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel

Associated Genotypes

Allelic Composition	Genetic Background
Slc27a4^tm1Wsr/Slc27a4^tm1Wsr	involves: 129P2/OlaHsd * C57BL/6