Phenotype Image Detail

Image

Caption

Morphological and histological analysis of Fkbp4^tm1Shou/Fkbp4^tm1Shou male mice. A: Growth curves of wild-type (WT) and Fkbp4^tm1Shou/Fkbp4^tm1Shou (FKBP52^-/-) mice. B: Comparison of adult wild-type and mutant male external genitalia at dorsal (a and b) and ventral (c and d) surfaces. The arrows (in b and d) indicate the underdeveloped foreskin and ectopic urethral opening at the ventral aspect compared with normal morphology in wild-type (a and c). Shown are histological sections of wild-type (e) and mutant (f) male genitalia. A red arrow indicates the ectopic urethral opening at the ventral aspect compared with normal morphology in wild-type (black arrows in e). C: Three-dimensional reconstruction of the mouse embryonic day 18.5 penises. Wire frame images of outer penile skin and urethra of the three genotypes are show in a, c and e. In b, d and f, the skins had been artificially removed. The glans penis is colored in gold, whereas the urethral opening is green, corpus cavernosum (cc) is purple, and the closed urethra is blue. Note that the urethral opening persisted throughout the mutant penile shaft, whereas normal controls only have a temporary urethral opening at the distal end. The side panels show representative sections of wild-type and mutant penises. The green arrows indicate open urethra, and blue arrows indicate closed urethra. D: Comparison of anogenital distances in wild-type, heterozygous and mutant mice. The anogenital distance, normalized by the animal body weight, was significantly shorter in mutant males compared with littermate wild-type and heterozygous males.

Copyright

This image is from Yong W, J Biol Chem 2007 Feb 16;282(7):5026-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120960

Associated Alleles

Symbol	Name
Fkbp4^tm1Shou	FK506 binding protein 4; targeted mutation 1, Weinian Shou

Associated Genotypes

Allelic Composition	Genetic Background
Fkbp4^tm1Shou/Fkbp4^tm1Shou	involves: 129S/SvEv