Phenotype Image Detail

Image

Caption

Morphological and histological comparison of tissues and organs from age-matched Fkbp4^tm1Shou/Fkbp4^tm1Shou and wild-type male mice. A: Morphological comparison of male internal reproductive organs in wild-type (WT, a) and Fkbp4^tm1Shou/Fkbp4^tm1Shou (FKBP52^-/-, b) adult mice. Mutant males have overall normal testis (Tes) formation and normal epididymis (Epi) but significantly smaller seminal vesicles (SV). Kid, kidney; Bl, bladder; Pe, penis. The black arrow indicates the urethral opening. B: Histological analysis of prostate gland development in mutant and age-matched wild-type mice at birth (P0) to 3 months old. Prostate glands are initially formed during embryonic development in both wild-type (a) and mutant (b) mice but lack further growth after birth (d) and eventually become dysgenic in mutant adult males (f) when compared with littermate wild-type mice (c and e). Prostate glands are indicated by black arrows.

Copyright

This image is from Yong W, J Biol Chem 2007 Feb 16;282(7):5026-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:120960

Associated Alleles

Symbol	Name
Fkbp4^tm1Shou	FK506 binding protein 4; targeted mutation 1, Weinian Shou

Associated Genotypes

Allelic Composition	Genetic Background
Fkbp4^tm1Shou/Fkbp4^tm1Shou	involves: 129S/SvEv