Phenotype Image Detail

Image

Caption

Mammary gland analysis in virgin female mice. Red carmine whole-mount staining (A-C) and hematoxylin and eosin staining of paraffin sections (D-F) of mammary glands of wild-type (+/+, A and D), Hras^tm2Xbr/Hras1⁺ (+/G12V, B and E), and Hras^tm2Xbr/Hras^tm2Xbr (G12V/G12V, C and F) mice. Insets show representative detail. Mammary glands of homozygous mutant mice displayed substantial white fat atrophy, greater ductal-lobulillar development (arrowheads), and ductal ectasia (asterisk). Scale bars: 1 mm (A-C); 10 um (D-F).

Copyright

This image is from Schuhmacher AJ, J Clin Invest 2008 Jun;118(6):2169-79 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:137729

Associated Alleles

Symbol	Name
Hras^tm2Xbr	Harvey rat sarcoma virus oncogene; targeted mutation 2, Xose R Bustelo

Associated Genotypes

Allelic Composition	Genetic Background
Hras^tm2Xbr/Hras^tm2Xbr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N