Phenotype Image Detail

Image

Caption

Facial dysmorphia. A: Top and side views of heads of wild-type (+/+) and Hras^tm2Xbr/Hras^tm2Xbr (G12V/G12V) mice illustrating the prominent forehead and blunt nose of the mutant mice (arrowheads). B: CT sections of wild-type and mutant littermates. Top: Coronal projection. Arrowhead indicates choanal atresia. Bottom: Sagittal projection. Arrowhead indicates the shortened and depressed nasal bridge and premaxillar bone.

Copyright

This image is from Schuhmacher AJ, J Clin Invest 2008 Jun;118(6):2169-79 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:137729

Associated Alleles

Symbol	Name
Hras^tm2Xbr	Harvey rat sarcoma virus oncogene; targeted mutation 2, Xose R Bustelo

Associated Genotypes

Allelic Composition	Genetic Background
Hras^tm2Xbr/Hras^tm2Xbr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N