Phenotype Image Detail

Image

Caption

Heart and kidney defects in Hras^tm2Xbr/Hras^tm2Xbr (G12V/G12V) mice. A: Formalin-fixed hearts. B: Hematoxylin and eosin stained heart ventricular sections. Interventricular wall (IV), left ventricle (LV) and right ventricle (RV) are indicated. C: Fibrosis in the LV, as shown by Sirius red-stained preparations. D: Hematoxylin and eosin stained aortic valves (arrowheads). E. Hematoxylin and eosin stained aorta media wall (asterisks). F: Kidney fibrosis, as shown by Sirius red-stained preparations. Scale bars: 1 mm (A and B); 50 um (D); 100 um (C, E and F).

Copyright

This image is from Schuhmacher AJ, J Clin Invest 2008 Jun;118(6):2169-79 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:137729

Associated Alleles

Symbol	Name
Hras^tm2Xbr	Harvey rat sarcoma virus oncogene; targeted mutation 2, Xose R Bustelo

Associated Genotypes

Allelic Composition	Genetic Background
Hras^tm2Xbr/Hras^tm2Xbr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N