Phenotype Image Detail

Image

Caption

A: Histological analysis (Hematoxylin and eosin staining) of paw skin of 1 day old wild-type (Col7a1^WT/WT) and Col7a1^tm1Lbt/Col7a1^tm1Lbt (Col7a1^flNeo/flNeo) mice shows dermal-epidermal blister formation (asterisk) with erythrocyte accumulation in the latter. B: Indirect immunofluorescence signal of collagen VII (green) in paw skin of 1 day old mutant mice was strongly reduced compared with wild-type mice. Asterisk indicates the blister cavity. Scale bars: 50 um (C and D). Ultrastructural analysis showed normal hemidesmosomes (white arrows), but few anchoring fibrils (black arrows), in the skin of mutant mice. Asterisk indicates the blister cavity. Original magnification, x195,000.

Copyright

This image is from Fritsch A, J Clin Invest 2008 May;118(5):1669-79 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:136145

Associated Alleles

Symbol	Name
Col7a1^tm1Lbt	collagen, type VII, alpha 1; targeted mutation 1, Leena Bruckner-Tuderman

Associated Genotypes

Allelic Composition	Genetic Background
Col7a1^tm1Lbt/Col7a1^tm1Lbt	involves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl