Phenotype Image Detail

Image

Caption

A and B: Kidney sections from 4 week old mice, stained with hematoxylin and eosin. Wild-type kidney (A) and Actn4^tm1Mrpk/Actn4^tm1Mrpk (Actn4-deficient) kidney (B) photographed at x10 magnification. C and D: At higher magnification (x40), glomerular abnormalities are clearly visible in the mutant mouse (D), but not in the wild-type littermate (C). The mutant kidney shows focal and segmental glomerulosclerosis (FSGS), with protein in tubules and areas of glomerular capillary collapse. A diseased glomerulus is indicated by an arrow (labeled "G"). A tubule filled with proteinaceous material is also indicated by an arrow (labeled "T"). E and F: Kidney sections from 10 week old mice, stained with H & E. E: Wild-type kidney. F: mutant kidney. The mutant kidney shows extensive disease, with sclerosed glomeruli, dilated tubules with proteinaceous material, and disrupted architecture. G: Gross appearance of wild-type (left) and mutant (right) kidneys from 10 week old mice.

Copyright

This image is from Kos CH, J Clin Invest 2003 Jun;111(11):1683-90 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:83911

Associated Alleles

Symbol	Name
Actn4^tm1Mrpk	actinin alpha 4; targeted mutation 1, Martin R Pollak

Associated Genotypes

Allelic Composition	Genetic Background
Actn4^tm1Mrpk/Actn4^tm1Mrpk	involves: 129 * C57BL/6