Phenotype Image Detail

Image

Caption

A and B: Electron microscopic appearance of kidneys from 10 day old wild-type (+/+) (A) and Actn4^tm1Mrpk/Actn4^tm1Mrpk (-/-) (B) littermates. C and D: Kidneys from 5 week old wild-type (C) and mutant (D) mice. E and F: Kidneys from 10 week old wild-type (E) and mutant (F) mice. In all cases, mutant mice showed altered glomerular ultrastructure. In the 10 day old kidney (B), there is mild disruption of the normal podocyte structure with focal areas of podocyte effacement. The disease is more extensive in the older mice (C and E). G and H: Early changes in mutant mice are shown at higher power. As shown in G, some mutant mice demonstrated areas with duplications, or "blebs", in the glomerular basement membrane (GBM) on the subepithelial aspect (arrow). These abnormalities were not seen in the control mice, nor were they present in all mutant mice. In H, focal areas of foot-process effacement in a mutant mouse is evident (arrow).

Copyright

This image is from Kos CH, J Clin Invest 2003 Jun;111(11):1683-90 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:83911

Associated Alleles

Symbol	Name
Actn4^tm1Mrpk	actinin alpha 4; targeted mutation 1, Martin R Pollak

Associated Genotypes

Allelic Composition	Genetic Background
Actn4^tm1Mrpk/Actn4^tm1Mrpk	involves: 129 * C57BL/6