Phenotype Image Detail

Image

Caption

Transmission electron micrographs of the terminal air sacs of E18.5 wild-type and Fras1^tm1Chpk/Fras1^tm1Chpk lungs. A and B: Ultrastructural analysis of the interface between endothelial and type I pneumocytes. The basement membrane (demarcated by arrowheads) appears significantly wider and less dense in mutants (B) compared with wild-type (A). C: Detachment of an endothelial cell from a type I pneumocyte (arrowheads) in mutant lungs. D: Extravasated erythrocytes (arrowheads) are frequently encountered in variable numbers in the respiratory lumen of mutant lungs. Abbreviations: lu, respiratory lumen; n, endothelial cell nucleus; p, type I pneumocyte; ery, erythrocyte. Scale bar: A-C, 200 nm; D, 1 um.

Copyright

This image is from Petrou P, J Biol Chem 2005 Mar 18;280(11):10350-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:137010

Associated Alleles

Symbol	Name
Fras1^tm1Chpk	Fraser extracellular matrix complex subunit 1; targeted mutation 1, George Chalepakis

Associated Genotypes

Allelic Composition	Genetic Background
Fras1^tm1Chpk/Fras1^tm1Chpk	involves: 129S1/Sv * 129X1/SvJ * NMRI