Phenotype Image Detail

Image

Caption

A: Histological views of wild-type (a-c) and Epb41l5^tm1Sia/Epb41l5^tm1Sia (EBP41L5^-/-) (a'-c') embryos at E6.5 (a and a'), E7.5 (b and b') and E8.5 (c and c'), respectively. (a, a' and b, and b') Horizontal sections. (c and c') Sagittal sections. Anterior is to the left. Bars, 100um. C: Electron microscopic views of mutant embryos. (a-j) Views in wild-type. (a'-j') Views in mutant embryos. (a and a') Views at E6.5 primitive streak. (b and b') Enlarged views of the regions boxed in a and a', respectively. (c and c') Views of the lateral region of E6.5 embryos. (d and d') Views of the anterior region of E7.5 embryos. (e-f') Enlarged views of the regions boxed in d and d'. (g and g') Views of laterally invaginated E7.5 mesoderm cells. (h and h') Views of cells invaginating at E7.5 primitive streak. (I and i') Enlarged views of the regions boxed in (h and h'). (j and j') Views of E7.5 endoderm cells. Dotted lines in d and d' outline individual cells in the anterior-most ectoderm layers; these cells are ectodermal, as suggested by the location of residual basement membrane components and E-cadherin expression shown in Fig. 4, b' and c'. Arrows in f and j indicate basement membranes. In e and e', TJ is tight junction; AJ, adherens junction; De, desmosome. Bars, 5 um.

Copyright

This image is from Hirano M, J Cell Biol 2008 Sep 22;182(6):1217-30, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:142596

Associated Alleles

Symbol	Name
Epb41l5^tm1Sia	erythrocyte membrane protein band 4.1 like 5; targeted mutation 1, Shinichi Aizawa

Associated Genotypes

Allelic Composition	Genetic Background
Epb41l5^tm1Sia/Epb41l5^tm1Sia	Not Specified