Phenotype Image Detail

Image

Caption

Immunohistochemical staining of heart (A) and liver (B) sections from wild-type and Rb1cc1^tm1.2Guan/Rb1cc1^tm1.2Guan embryos at E12.5 or E14.5 with antibody against cleaved caspase-3. There is no immunostaining observed in heart or liver sections from either the mutant or wild-type embryo section at E12.5 or in the wild-type embryo at E14.5. In contrast, in the mutant embryo at E14.5, selected myocardial cells (arrows) show intense cytoplasmic and nuclear staining. Many hepatocytes also show intense cytoplasmic and nuclear staining. In the high-magnification inset, selected hepatocytes are marked with arrows.

Copyright

This image is from Gan B, J Cell Biol 2006 Oct 9;175(1):121-33, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:114498

Associated Alleles

Symbol	Name
Rb1cc1^tm1.2Guan	RB1-inducible coiled-coil 1; targeted mutation 1.2, Jun-Lin Guan

Associated Genotypes

Allelic Composition	Genetic Background
Rb1cc1^tm1.2Guan/Rb1cc1^tm1.2Guan	involves: 129P2/OlaHsd * C57BL/6