Phenotype Image Detail

Image

Caption

Paraffin sections of the normal (a) and Upk2^tm1Tsun/Upk2^tm1Tsun (b) bladders of 1 month old male mice were stained with hematoxylin and eosin. Those of normal (c) and mutant (d) bladders of 19 day old male mice were isolated 2 hours after the final i.p injection of BrdU and were stained immunohistochemically for BrdU. The inset in c shows an area with some BrdU-incorporating superficial cells. Note the increased thickness and the elevated BrdU incorporation (10.7 1.1% vs. 0.12 0.07%) of the mutant urothelium. Also note that although most of the labeling occurred in basal cells (arrows), there was occasional labeling of superficial cells (arrowheads). A total of eight mutant and eight normal mice, half of them male, were studied; 1,000-2,000 urothelial cells were examined per section from each animal; P <0.001; with no significant gender differences. Bar, 50um.

Copyright

This image is from Kong XT, J Cell Biol 2004 Dec 20;167(6):1195-204, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:95622

Associated Alleles

Symbol	Name
Upk2^tm1Tsun	uroplakin 2; targeted mutation 1, Tung-Tien Sun

Associated Genotypes

Allelic Composition	Genetic Background
Upk2^tm1Tsun/Upk2^tm1Tsun	involves: 129S/SvEv * Black Swiss