Phenotype Image Detail

Image

Caption

Histological analysis of articular cartilage of Smad3^tm1Cxd/Smad3^tm1Cxd mice. A and B: Knee joints of P30 wild-type (A) and mutant (B) mice. Notice the increased number of hypertrophic chondrocytes in mutant articular cartilage. C-F: Knee joints of 4 (C and D) and 7 month old (E and F) wild-type (C and E) and mutant (D and F) mice. Arrow points to abnormally accumulated layer of chondrocytes (D). G-J: Osteophytes found in synovium of 7 month old mice. Arrows point to osteophytes, hematoxylin and eosin (G), collagen type II (H), collagen type I (I), and osteocalcin (J) expression in osteophytes. Bar: (A and B) 150 um; (C-J) 100 um.

Copyright

This image is from Yang X, J Cell Biol 2001 Apr 2;153(1):35-46, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:68792

Associated Alleles

Symbol	Name
Smad3^tm1Cxd	SMAD family member 3; targeted mutation 1, Chu-Xia Deng

Associated Genotypes

Allelic Composition	Genetic Background
Smad3^tm1Cxd/Smad3^tm1Cxd	involves: 129S6/SvEvTac