Phenotype Image Detail

Image

Caption

Bone formation in mice. A: Microcomputed tomography (uCT) three-dimensional images of wild-type (WT), Wwox^tm1Ria/Wwox⁺ (HT) and Wwox^tm1Ria/Wwox^tm1Ria (KO) genotypes at the indicated ages. Top panel, image from the midsection of femur that shows less trabecular bone and a delay in the secondary center of ossification in the mutant; middle panel, cross-section at mid-diaphysis shows thin cortical bone of mutant. B: Quantitation of selected bone formation parameters, including bone volume, mineral density, area of bone formation surfaces, and cortical bone quality from uCT data analyses as indicated.

Copyright

This image is from Aqeilan RI, J Biol Chem 2008 Aug 1;283(31):21629-39 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:138140

Associated Alleles

Symbol	Name
Wwox^tm1Ria	WW domain-containing oxidoreductase; targeted mutation 1, Rami I Aqeilan

Associated Genotypes

Allelic Composition	Genetic Background
Wwox^tm1Ria/Wwox^tm1Ria	involves: 129X1/SvJ * C57BL/6J