Phenotype Image Detail

Image

Caption

The kidneys of wild-type (a,c and e) and Upk2^tm1Tsun/Upk2^tm1Tsun (b,d and f) mice were compared in terms of their gross appearance (a and b), whole kidney section (c and d), and histological appearance (e and f). The mice used were 6 months old for a and b, and 3 months old for c-g. g shows a plot of renal pressure (PM-PR) versus the grade of hydronephrosis (D/T, where D and T were the diameter of the renal pelvis cavity and the thickness of the renal parenchyma, respectively). More than 100 knockout mice were studied and ~80% of them showed various degrees of hydronephrosis. Note a lack of positive correlation between the grade of hydronephrosis and renal pressure (Pk) (t test, t=0.177, P > 0.2), which suggests that reflux could not be a major cause of hydronephrosis. (c,e and f) C, cortex; G, glomeruli; M, medulla; T, tubules; U, urothelium. Bar, 50 um.

Copyright

This image is from Kong XT, J Cell Biol 2004 Dec 20;167(6):1195-204, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:95622

Associated Alleles

Symbol	Name
Upk2^tm1Tsun	uroplakin 2; targeted mutation 1, Tung-Tien Sun

Associated Genotypes

Allelic Composition	Genetic Background
Upk2^tm1Tsun/Upk2^tm1Tsun	involves: 129S/SvEv * Black Swiss