Phenotype Image Detail

Image

Caption

I.v. pyelogram of wild-type (a) and Upk2^tm1Tsun/Upk2^tm1Tsun mice (b) established delayed excretion of contrast in the latter. c-h show the histological sections of the ureters of wild-type (c and e), mutant (d and f), and Upk3a^tm1Tsun/Upk3a^tm1Tsun (g and h) mice. Samples were taken from proximal (c and d) or distal (e-h) ureter. Note the formation of epithelial outgrowth filling the ureteral lumen (f), sometimes forming a complete occlusion (h). B, bladder; EO, epithelial occlusion; EP, epithelial plug; K, kidney; L, lumen. Bar, 50um

Copyright

This image is from Kong XT, J Cell Biol 2004 Dec 20;167(6):1195-204, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:95622

Associated Alleles

Symbol	Name
Upk2^tm1Tsun	uroplakin 2; targeted mutation 1, Tung-Tien Sun
Upk3a^tm1Tsun	uroplakin 3A; targeted mutation 1, Tung-Tien Sun

Associated Genotypes

Allelic Composition	Genetic Background
Upk2^tm1Tsun/Upk2^tm1Tsun	involves: 129S/SvEv * Black Swiss