Phenotype Image Detail

Image

Caption

Cardiac defects. A: Images of E10.5 wild-type (+/+) and Cert1^{Gt(RRF047)Byg}/Cert1^{Gt(RRF047)Byg} (-/-) embryos. The heads were removed to facilitate the observation of the heart. In, general, the mutant hearts were proportionately (relative to the size of the embryo) larger and thinner in the mutant compared with the wild-type. B, top: The same embryos in A were photographed from the other side to get a view of the left ventricle (LV), which, in this instance, appeared to have an area of increased density in the mutant embryo. The left bottom panel shows a mutant heart with accumulated blood in the left ventricle, and the panel on the right highlights the thin walls of the outflow tract (oft) and the left ventricle in the mutant hearts. C: Hematoxylin and eosin sections of the wild-type and mutant heart show the proportionately larger heart of the mutant with thin-walled ventricles and the outflow tracts. The inset shows a high magnification view of the outflow tract. In this instance, the mutant outflow tract is larger, thin walled, and increased the amount of the acellular cardiac jelly seen inside the cavity.

Copyright

This image is from Wang X, J Cell Biol 2009 Jan 12;184(1):143-58, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:146172

Associated Alleles

Symbol	Name
Cert1^Gt(RRF047)Byg	ceramide transporter 1; gene trap RRF047, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Cert1^Gt(RRF047)Byg/Cert1^Gt(RRF047)Byg	involves: 129P2/OlaHsd * C57BL/6