Phenotype Image Detail

Image

Caption

Histological analysis of Capn3^tm1Jsb/Capn3^tm1Jsb mice. Hematoxylin and eosin stained transverse muscle cryosections (7um) from mice of 129/Sv genetic background. A-D: 2 month old mice; E-L: 6 month old mice. Dystrophic changes are evident in psoas (A and E), soleus (B and F), deltoid (C and G), and tibialis anterior (D and H), whereas quadriceps (I), gastrocnemius (J), and triceps (K) present a normal aspect. Diaphragm in L presents very slight abnormalities. The main features encountered are fibers with internal nuclei (B-F, and H) or area of infiltration of mononuclear cells (A and G). A cluster of small regenerating fibers can be seen in E. Bars, 50 um.

Copyright

This image is from Richard I, J Cell Biol 2000 Dec 25;151(7):1583-90, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:66862

Associated Alleles

Symbol	Name
Capn3^tm1Jsb	calpain 3; targeted mutation 1, Jacques S Beckmann

Associated Genotypes

Allelic Composition	Genetic Background
Capn3^tm1Jsb/Capn3^tm1Jsb	either: 129/Sv-Capn3^tm1Jsb or (involves: 129/Sv * C57BL/6)