Phenotype Image Detail

Image

Caption

Adrenal hypertrophy. A: Gross anatomy of wild-type (WT, left panel) and Cyp11b1^tm1Chjk/Cyp11b1^tm1Chjk (null, right panel) adrenal glands. B: Histological sections of wild-type (left hand panels) and mutant (right hand panels) adrenal glands showing extent of zona fasciculata (ZF, upper panels) and degree of hypertrophy (lower panels). Size markers are shown in the top left-hand corner of each image. C: Attenuated stress response in male mutant mice subjected to serial blood sampling protocol (during glucose tolerance test). Values shown are means +/- S.E. *indicates significant difference (p < 0.001) of plasma corticosterone values from mutant compared with wild-type mice at each time point. ip inj, intraperitoneal injection.

Copyright

This image is from Mullins LJ, J Biol Chem 2009 Feb 6;284(6):3925-34 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147610

Associated Alleles

Symbol	Name
Cyp11b1^tm1Chjk	cytochrome P450, family 11, subfamily b, polypeptide 1; targeted mutation 1, Christopher J Kenyon

Associated Genotypes

Allelic Composition	Genetic Background
Cyp11b1^tm1Chjk/Cyp11b1^tm1Chjk	involves: 129P2/OlaHsd * C57BL/6J