Phenotype Image Detail

Image

Caption

Thbd^tm2Rdr/Thbd^tm2Wlr Tg(Tek-cre)1Ywa/0 mice develop hemorrhagic lesions and organ necrosis and succumb to consumptive coagulopathy. (a) Typical necrotic lesion of the skin, the ears, and the tail in mutant mice. Early and small hemorrhagic skin lesions (b) subsequently progress into larger necrotic lesions (c and d; left foot in d: control littermate). (e) Macroscopic specimen of a mouse with priapism: hemorrhagic necrosis of the penis (arrow) and testis (arrowhead). (f and g) Multiple necrosis of the liver (f, arrows) and swollen, hemorrhagic liver lobe (g, arrows) in mutant mice (arrowhead in g: unaffected liver tissue). (h) Gastrointestinal bleeding at the disease end-stage in a mutant mouse. (i) Multiple hemorrhagic lesions in the lung of a mutant mouse.

Copyright

This image is from Isermann B, J Clin Invest 2001 Aug;108(4):537-46 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:71269

Associated Alleles

Symbol	Name
Tg(Tek-cre)1Ywa	transgene insertion 1, Masashi Yanagisawa
Thbd^tm2Rdr	thrombomodulin; targeted mutation 2, Robert D Rosenberg
Thbd^tm2Wlr	thrombomodulin; targeted mutation 2, Harmut Weiler

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Tek-cre)1Ywa/0 Thbd^tm2Rdr/Thbd^tm2Wlr	involves: 129S2/SvPas * C57BL/6 * SJL