Phenotype Image Detail

Image

Caption

Histological analyses revealed multiple pathological findings in Thbd^tm2Rdr/Thbd^tm2Wlr Tg(Tek-cre)1Ywa/0 mice. (a) Intravascular thrombi in a peripheral vein (arrow) and the adjacent artery (arrowhead); hematoxylin and eosin (H&E) stain. (b) Intravascular thrombus in the liver, partially occluding a liver vein; H&E stain. (c and e) Trichrome stain of lung sections from mutant (c) and control (e) mice. Increased extracellular matrix content in the lung interstitium is associated with a marked destruction of the lung architecture and a loss of alveolar septa. (d and f) Trichrome stain of heart sections from mutant (d) and control (f) mice; multiple sites of myocardial fibrosis in the mutant heart. Original magnification is indicated at lower right.

Copyright

This image is from Isermann B, J Clin Invest 2001 Aug;108(4):537-46 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:71269

Associated Alleles

Symbol	Name
Tg(Tek-cre)1Ywa	transgene insertion 1, Masashi Yanagisawa
Thbd^tm2Rdr	thrombomodulin; targeted mutation 2, Robert D Rosenberg
Thbd^tm2Wlr	thrombomodulin; targeted mutation 2, Harmut Weiler

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Tek-cre)1Ywa/0 Thbd^tm2Rdr/Thbd^tm2Wlr	involves: 129S2/SvPas * C57BL/6 * SJL