Phenotype Image Detail

Image

Caption

Comparative analyses of skull and axial skeleton between wild-type (+/+) (A,C,E,I,K,M) and Fgf9^Eks/Fgf9^Eks (Eks/Eks) (B,D,F,J,L,N) mice. A,B: Lateral views of the skulls. Note the abnormal skull shape manifested by a tall forehead as indicated by the red arrow, and the mid-face hypoplasia due to the shortened nasal bone. Nasal bones are indicated by red asterisks. C,D: Dorsal views of the skulls showing premature fusion of the coronal (C) and sagittal (S) sutures and widely spaced eyes, as indicated by red arrows in the mutant. E,F: Ventral views of the skull base. In the wild-type, palatal shelves of the maxilla (indicated by the red arrow in E) and palatine (yellow asterisk) formed the secondary palate, In a homozygous mutant, palatal shelves of the maxilla (indicated by the red arrow in F) and palatine (indicated by yellow arrowheads) failed to fuse at the midline. bs, basisphenoid; bo, basioccipital bone. G: Lateral views of isolated temporal bones. Tympanic rings and Meckel's cartilages are indicated by red and black arrowheads, respectively. Note hypertrophy of the temporal bone in homozygous mutants. H: Cranial views of isolated temporal bones. Cochleas are indicated by parentheses. Note hypertrophy of the cochlea in mutants. I, J: Lateral views of cerviothoracic regions. The parentheses in J indicate extensive fusions of laminae of the neural arches. K,L: Ventral views of thoracic regions. M,N: Ventral views of the thorax. Width of the sternums are represented by parentheses.

Copyright

This image is from Murakami H, Mamm Genome 2002 Jul;13(7):341-4 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:77537

Associated Alleles

Symbol	Name
Fgf9^Eks	fibroblast growth factor 9; elbow knee synostosis

Associated Genotypes

Allelic Composition	Genetic Background
Fgf9^Eks/Fgf9^Eks	involves: C57BL/6J * DBA/2J