Phenotype Image Detail

Image

Caption

Cardiac development defects. A: Under-presentation of Smad7^tm1.1Shou/Smad7^tm1.1Shou (-/-) mice. The table summarizes the number of mice that survived to weaning stage. B: Summary of cardiac phenotypes of mutant embryos at E14.5 and E16.5. C and D: Embryo images and histological analyses of mutant mice at E14.5 and E16.5. Note that the mutant mice had edema in the dorsal region (marked by *). Transverse heart sections (right panels) at atrioventricular valve level showed a ventricular septal defect (VSD, arrowheads) and ventricular non-compaction (arrows). RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; and VS, ventricular septum. E: Neonatal mutant mouse was smaller and pale in comparison with wild-type (+/+) littermate (left panel). Transverse heart sections (right panel) revealed VSD (arrowhead) and ventricular non-compaction (arrow). F: Outflow tract defects in a mutant mouse. The positioning of aorta (A) relative to pulmonary artery (P) was altered in mutant embryos at E16.5.

Copyright

This image is from Chen Q, J Biol Chem 2009 Jan 2;284(1):292-300 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:145777

Associated Alleles

Symbol	Name
Smad7^tm1.1Shou	SMAD family member 7; targeted mutation 1.1, Weinian Shou

Associated Genotypes

Allelic Composition	Genetic Background
Smad7^tm1.1Shou/Smad7^tm1.1Shou	involves: C57BL/6 * FVB