Phenotype Image Detail

Image

Caption

Wild-type (HSL^+/+, a) and Lipe^tm1Gam/Lipe^tm1Gam (HSL^-/-, b) mice at 6, 8 (c,d) and 12 weeks. Tubules at stage VII of the cycle from mutant mice at 6 weeks of age (b) reveal a reduction in the frequency of elongating step 16 spermatids (arrowheads), as well as multinucleation (curved arrows) and disoriented heads (arrow, inset), unlike that seen in wild-type mice (a). At 8 weeks, a stage I tubule from mutant mice (c) shows a reduction in frequency of of step 13 elongating spermatids (arrowheads) with some being disoriented (circle) and revealing abnormal shapes (arrows). Multinucleation of elongating spermatids is also seen (curved arrow). At stage VII (d) some step 16 spermatid heads are disoriented and appear embedded together in a single spherical cytoplasm that is highly vacuolated (curved arrows), moderately stained and situated close to the lumen. At 12 weeks (e,f) step 16 spermatids at stage VII were virtually absent. The few remaining spermatids are multinucleated and disoriented (curved arrows, e and f). Large cavities (stars) are alos seen within the seminiferous epithelium (e,f). There is also evidence of multinucleation of occasional round spermatids (open arrow), and some round spermatids (small arrows, f) appear to be released into the lumen (Lu). Original magnification (a-f), 448x; (b, inset), 1,120x.

Copyright

This image is from Hermo L, Mol Reprod Dev 2008 Apr;75(4):565-77, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:134794

Associated Alleles

Symbol	Name
Lipe^tm1Gam	lipase, hormone sensitive; targeted mutation 1, Grant A Mitchell