Phenotype Image Detail

Image

Caption

Two regions of full-thickness epidermis from the trunk of a Sfn^Er/Sfn^Er mouse. (a) Basal (B) and lower spinous (S) cells are widely separated and contain phagolysosomes (PhLy). One layer of spinous cells separates basal and granular (G) cells. Granular cells extend all the way to the epidermal surface as indicated by the keratohyalin granules (KHG and arrows) in the cytoplasm, x2500. Inset: Spherical inclusions within mitochondria found in cells of basal, spinous and granular layers. x21,000. (b) Granular cells have minute KHG that would not be distinguishable at the LM level. The intercellular spaces are wide among basal and lower spinous cells. x2,500. Nonkeratinized cells form the epidermal surface in both samples.

Copyright

This image is from Holbrook KA, J Cell Biol 1982 Feb;92(2):387-97, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:6708

Associated Alleles

Symbol	Name
Sfn^Er	stratifin; repeated epilation

Associated Genotypes

Allelic Composition	Genetic Background
Sfn^Er/Sfn^Er	involves: 129/Sv * C57BL/6