Phenotype Image Detail

Image

Caption

Upper epidermal layers from Sfn^Er/Sfn^Er mice showing various states of partial keratinization. (a) A normally differentiated keratinized squame (Sq) is embedded among granular cells (G). Expelled lamellar granules (LG and arrows) completely surround this cell. Two cells (A and B) at the surface show certain features of keratinization including a cornified cell envelope and a depletion of most organelles. x6,600. Inset, x22,500. (b) Surface keratinocytes showing varying states of terminal differentiation. All three cells (C,D and E) have a cornified cell envelope (CCE). Cell E still has keratohyalin granules (KHG), a pyknotic nucleus (N), and large dense bundles of keratin filaments (KF); the cytoplasm is dense. Extruded lamellar granules (arrows) fill the extracellular space around cell E. Cells C and D contain primarily keratin filaments. The remnant of an organelle is seen in cell D. x13,200.

Copyright

This image is from Holbrook KA, J Cell Biol 1982 Feb;92(2):387-97, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:6708

Associated Alleles

Symbol	Name
Sfn^Er	stratifin; repeated epilation

Associated Genotypes

Allelic Composition	Genetic Background
Sfn^Er/Sfn^Er	involves: 129/Sv * C57BL/6