Phenotype Image Detail

Image

Caption

Ultrastructural analysis of skin from Dcn^tm1Ioz/Dcn^tm1Ioz mice reveals abnormal collagen fibrillogenesis. A-C: Transmission electron micrographs of dermal collagen from Dcn^tm1Ioz/Dcn^tm1Ioz (A and B) and wild-type (C) mice. Notice the presence of larger (>200 nm) and irregular fibrils (A and B, asterisks) and the coexistence of smaller (30-40 nm) fibrils (A, circles) in the mutant. Note also the presence of coarser fibrils exhibiting lateral fusion to an adjacent tapered segment (B, arrowheads). In contrast, collagen from the wild-type mouse (C) showed a more compact and uniform pattern of fibril diameter and distribution.

Copyright

This image is from Danielson KG, J Cell Biol 1997 Feb 10;136(3):729-43, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:39212

Associated Alleles

Symbol	Name
Dcn^tm1Ioz	decorin; targeted mutation 1, Renato V Iozzo

Associated Genotypes

Allelic Composition	Genetic Background
Dcn^tm1Ioz/Dcn^tm1Ioz	involves: 129S1/Sv * 129X1/SvJ * Black Swiss