Phenotype Image Detail

Image

Caption

Neuropathological analysis. A-D: Toluidine blue-stained cross sections of rhinencephalon areas of wild-type (A and C) and Kif1a^tm1Noh/Kif1a^tm1Noh (B and D) mice. The focal lesion (dotted region) in the piriform cortex and endopiriform nucleus shows severe degeneration of neuronal cells and a large number of vacuoles surrounding the degenerative cells in the mutant mice. A higher-magnification view of the degenerative lesion (D). OT, lateral olfactory tract; PC, piriform cortex; EN, endopiriform nucleus. E and F: Electron micrographs of cross sections of the fimbrias of hippocampi of wild-type (E) and mutant (F) mice. Massive degeneration of many axons (arrows) occurred in the mutant mice. The axons are very dilated and filled with membranous organelles. Bars: A and B, 100 um; C and D, 25 um; E and F, 1 um.

Copyright

This image is from Yonekawa Y, J Cell Biol 1998 Apr 20;141(2):431-41, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:47170

Associated Alleles

Symbol	Name
Kif1a^tm1Noh	kinesin family member 1A; targeted mutation 1, Nobutaka Hirokawa

Associated Genotypes

Allelic Composition	Genetic Background
Kif1a^tm1Noh/Kif1a^tm1Noh	involves: 129S4/SvJae * C57BL/6