Phenotype Image Detail

Image

Caption

Time course of changes in ventral roots of old mice. Light microscopy of toluidine blue-stained cross sections of L5 ventral roots from wild-type (A,D and G), Nefm^tm1Ral/Nefm^tm1Ral (NF-M; B,E and H) and Nefm^tm1Ral/Nefm^tm1Ral Nefh^tm1Ral/Nefh^tm1Ral (NF-M/H; C,F and I) at 4 months (A-C), 1 year (D-f) or 2 years (G-I) of age. Myelinated axons in the ventral roots of the 4 month and 1 year old single and double homozygous mutant mice, although reduced in size, are otherwise normal in appearance. By contrast, axons in the ventral roots of the 2 year old mutants appear shrunken and frequently irregular in shape. Bar, 10 um.

Copyright

This image is from Elder GA, J Cell Biol 1999 Jul 12;146(1):181-92, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77656

Associated Alleles

Symbol	Name
Nefh^tm1Ral	neurofilament, heavy polypeptide; targeted mutation 1, Robert A Lazzarini
Nefm^tm1Ral	neurofilament, medium polypeptide; targeted mutation 1, Robert A Lazzarini

Associated Genotypes

Allelic Composition	Genetic Background
Nefm^tm1Ral/Nefm^tm1Ral	involves: 129S1/Sv * 129X1/SvJ
Nefh^tm1Ral/Nefh^tm1Ral	involves: 129S1/Sv * 129X1/SvJ
Nefh^tm1Ral/Nefh^tm1Ral Nefm^tm1Ral/Nefm^tm1Ral	involves: 129S1/Sv * 129X1/SvJ