Phenotype Image Detail

Image

Caption

Fine structure of axons in old mice. Lumbar root axons from 2 year old wild-type (A), Nefm^tm1Ral/Nefm^tm1Ral (NF-M, B), Nefh^tm1Ral/Nefh^tm1Ral (NF-H, C), and Nefm^tm1Ral/Nefm^tm1Ral Nefh^tm1Ral/Nefh^tm1Ral (NF-M/H, D) mice are shown. In ventral roots of the Nefm^tm1Ral/Nefm^tm1Ral mice (B), neurofilaments are sparse and the microtubules are plentiful, whereas axoplasm of the double homozygous mutant (D) contains only microtubules. Wild-type (A) and Nefh^tm1Ral/Nefh^tm1Ral mice (C) show numerous neurofilaments and fewer microtubules. Bar, 200 nm.

Copyright

This image is from Elder GA, J Cell Biol 1999 Jul 12;146(1):181-92, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77656

Associated Alleles

Symbol	Name
Nefh^tm1Ral	neurofilament, heavy polypeptide; targeted mutation 1, Robert A Lazzarini
Nefm^tm1Ral	neurofilament, medium polypeptide; targeted mutation 1, Robert A Lazzarini

Associated Genotypes

Allelic Composition	Genetic Background
Nefm^tm1Ral/Nefm^tm1Ral	involves: 129S1/Sv * 129X1/SvJ
Nefh^tm1Ral/Nefh^tm1Ral	involves: 129S1/Sv * 129X1/SvJ
Nefh^tm1Ral/Nefh^tm1Ral Nefm^tm1Ral/Nefm^tm1Ral	involves: 129S1/Sv * 129X1/SvJ