Phenotype Image Detail

Image

Caption

Heart development. Corresponding horizontal sections of E12.5 wild-type (c-jun +/+, A) and Jun^tm1Wag/Jun^tm1Wag mouse fetuses (c-jun -/-, B) were stained with hematoxylin and eosin. At this stage of development, wild-type fetuses show separation of the aorta (ao) and the pulmonary trunk (pt). In mutant fetuses (B) there is a single outflow vessel (arrow) that arises from the right ventricle. Corresponding horizontal sections through the hearts of E14.5 wild-type (C,E and G) and mutant fetuses (D,F and H). The sections are arranged from cranial to caudal and show three major anomalies : (a) persistence of the right branch of the 4th aortic arch artery (aa in D), (b) persistent truncus arteriosus (pta in F) whereas the wild-type littermate show complete separation of the aorta and pulmonary trunk (arrow in E), and (c) incomplete septation of the ventricles (arrow in H). ao, aorta; pt, pulmonary trunk; rv, right ventricle; lv, left ventricle; ra, right atrium; la, left atrium; aa, aortic arch; tr, trachea; oe, oesophagus; th, thymus; pv, pulmonary valve; pta, persisting truncus arteriosus; av, aortic valve; vs, ventricular septum, Bars, 200 um.

Copyright

This image is from Eferl R, J Cell Biol 1999 May 31;145(5):1049-61, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55508

Associated Alleles

Symbol	Name
Jun^tm1Wag	jun proto-oncogene; targeted mutation 1, Erwin F Wagner

Associated Genotypes

Allelic Composition	Genetic Background
Jun^tm1Wag/Jun^tm1Wag	involves: 129S2/SvPas * C57BL/6