Phenotype Image Detail

Image

Caption

Histological analyses of Kif3a^tm1Noh/Kif3a^tm1Noh embryos at 9.5 dpc. Sagittal section of a wild-type (A) and a Kif3a^tm1Noh/Kif3a^tm1Noh (B) embryo. Systemic hypoplasia, extended pericardium (arrows) and thinning of neural tube wall (arrowheads) are characteristic of the homozygotes. Frontal sections of both type of embryos (C, wild-type; D, homozygote) display striking differences as described in the sagittal sections. Cardiac insufficiency in homozygotes is partly explained by hypoplastic myocardium (F). Note the well-developed myocardial wall in the case of the wild-type (E) embryos. Bars, 1 mm.

Copyright

This image is from Takeda S, J Cell Biol 1999 May 17;145(4):825-36, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55332

Associated Alleles

Symbol	Name
Kif3a^tm1Noh	kinesin family member 3A; targeted mutation 1, Nobutaka Hirokawa

Associated Genotypes

Allelic Composition	Genetic Background
Kif3a^tm1Noh/Kif3a^tm1Noh	involves: 129S4/SvJae * C57BL/6J