Phenotype Image Detail

Image

Caption

Ultrastructure of synapses in Colq^tm1Jrs/Colq^tm1Jrs mice. Electron micrographs from P20 control (a), P20 Colq^tm1Jrs/Colq^tm1Jrs (b), and p180 mutant (c and d) muscles. In controls, nerve terminals lie atop a folded postsynaptic membrane and are capped by processes of Schwann cells. In mutants, the subsynaptic cytoplasm appears necrotic at some synapses (b), and some nerve terminals are enwrapped by Schwann cells (d). Even at 6 months of age, however, some mutant synapses appear normal (c). Bar, 1 um.

Copyright

This image is from Feng G, J Cell Biol 1999 Mar 22;144(6):1349-60, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:54006

Associated Alleles

Symbol	Name
Colq^tm1Jrs	collagen like tail subunit of asymmetric acetylcholinesterase; targeted mutation 1, Joshua R Sanes
Colq^tm2Jrs	collagen like tail subunit of asymmetric acetylcholinesterase; targeted mutation 2, Joshua R Sanes

Associated Genotypes

Allelic Composition	Genetic Background
Colq^tm1Jrs/Colq^tm1Jrs	involves: 129S1/Sv * 129X1/SvJ
Colq^tm2Jrs/Colq^tm2Jrs	involves: 129S1/Sv * 129X1/SvJ