Phenotype Image Detail

Image

Caption

Agtpbp1^pcd/Agtpbp1^pcd mice show a moderate ataxia beginning at 3 to 4 weeks. Mutant mice are somewhat smaller than normal but may live a fairly normal life span. Males have abnormal sperm and are sterile. Females are fertile but are poor breeders. There is rapid degeneration of nearly all Purkinje cells beginning at 15 to 18 days, and a slower degeneration of the photoreceptor cells of the retina and mitral cells of the olfactory bulb.

Copyright

Photo courtesy of Mouse Mutant Resource at The Jackson Laboratory. https://www.jax.org/research-and-faculty/tools/mouse-mutant-resource J:110244

Associated Alleles

Symbol	Name
Agtpbp1^pcd	ATP/GTP binding protein 1; Purkinje cell degeneration

Associated Genotypes

Allelic Composition	Genetic Background
Agtpbp1^pcd/Agtpbp1^pcd	B6.BR-Agtpbp1^pcd/J