Phenotype Image Detail

Image

Caption

Mbp^shi/Mbp^shi mice show a generalized tremor during locomotion from 12 days of age. This shivering increases in severity with age, and there is incoordination of the hindlimbs. Post-weaning mice undergo seizure-like attacks during which they may lie rigid and motionless for many seconds. Mutants are noticeably smaller than their littermates by 4 weeks of age and their life span is shortened.

Copyright

Photo courtesy of Mouse Mutant Resource at The Jackson Laboratory. https://www.jax.org/research-and-faculty/tools/mouse-mutant-resource J:110244

Associated Alleles

Symbol	Name
Mbp^shi	myelin basic protein; shiverer

Associated Genotypes

Allelic Composition	Genetic Background
Mbp^shi/Mbp^shi	C3Fe.SWV-Mbp^shi/J