Phenotype Image Detail

Image

Caption

Electron micrographs of labyrinth of E11.5 wild-type (A and B; SynA^+/+) and Syna^tm1.1Ics/Syna^tm1.1Ics (C-G; Syna^-/-) placentae. A: Three-layered interhemal barrier of wild-type labyrinth at the maternofetal interface [m indicates maternal blood lacuna with darkly stained erythrocytes, and f indicates fetal blood vessel lined by endothelial cells (ec) with a nucleated erythrocyte] with the mononuclear sinusoidal trophoblast giant cells (stgc) and the 2 syncytiotrophoblast (ST-I and ST-II) layers delineated, and the ST-II-specific lipid inclusions indicated with asterisks. B: Expanded view of the area boxed in A, showing tight apposition of the ST-I and ST-II layers (outlines of the facing cytoplasmic membranes schematized on the Right). (C and D) same as A and B for the mutant placenta, with the 3-layered structure still present (C) but with severe disturbance of the putative ST-I (T-I) layer and disrupted interactions with ST-II (D, facing cytoplasmic membranes outlined on the Right); ST-II appears normal (typical lipid inclusions indicated by asterisks). (E and F) Images of unfused T-I cells as observed in less-disturbed mutant interhemal domains. Apposed cytoplasmic extensions (arrows) are schematized on the Right. G: Apoptotic cell (arrow) with cup-shaped condensed chromatin, in contact (yellow dotted line) with a sinusoidal trophoblast giant cell (stgc) and the ST-II layer. Scale bars: 2 um.

Copyright

This image is from Dupressoir A, Proc Natl Acad Sci U S A 2009 Jul 21;106(29):12127-32. Copyright 2009 National Academy of Sciences, U.S.A. J:150813

Associated Alleles

Symbol	Name
Syna^tm1.1Ics	syncytin a; targeted mutation 1.1, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Syna^tm1.1Ics/Syna^tm1.1Ics	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL