Phenotype Image Detail

Image

Caption

Wild-type (A,B) and Rab23^opb/Rab23^opb (C-F) fetuses at day 15 post coitum of development. Skeletal preparations of a wild-type (B) and mutant (D) fetus stained with alcian blue for cartilage and alizarin red for bone. In mutant fetuses (C,E), eyes were missing, the limbs exhibited preaxial duplications, the skin of the rostral body was detached dorsally, and spinal cords were open dorsally in lumbo-sacral (C) or thoracolumbar (E) axial regions (arrows). In the trunk region of mutant fetuses, the spinal cord defects were accompanied by neural arches which remained wide open dorsally (D, arrowheads) as compared with wild-type fetuses (B, arrowheads). Neural arches in the cervical axial region of wild-type (arrows in D) as well as mutant fetuses (arrows in B) were nearly closed. (F) Dorsal view of open aspect of the mutant spinal cord in E shown at higher magnification. Orientation of fetuses: rostral to the left.

Copyright

This image is from Gunther T, Mamm Genome 1997 Aug;8(8):583-5 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:42171

Associated Alleles

Symbol	Name
Rab23^opb	RAB23, member RAS oncogene family; open brain

Associated Genotypes

Allelic Composition	Genetic Background
Rab23^opb/Rab23^opb	B6.Cg-Rab23^opb