Phenotype Image Detail

Image

Caption

Histology of the descending colon. The two panels at top depict the histology of the full thickness of the wall of colons extirpated from wild-type (WT) mice fed normal laboratory chow (top left) and from Gfus^tm1Jbl/Gfus^tm1Jbl (FX(-/-)) mice fed fucose-supplemented chow (2.5% wt/wt) (top right). The wall of the colon in mutant mice reared in the absence of fucose is roughly twice the normal thickness, necessitating separate panels that display the basal (bottom left) and the lumenal (bottom right) aspects of the fucose-deficient mutant colon wall. Black arrows identify crypt abscesses. Red arrows delimit areas of mixed inflammatory cell infiltrate that expand the lamina propria, including a plasma cell infiltrate beneath the base of and between crypts. Hematoxylin and eosin stain.

Copyright

This image is from Smith PL, J Cell Biol 2002 Aug 19;158(4):801-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:82239

Associated Alleles

Symbol	Name
Gfus^tm1Jbl	GDP-L-fucose synthase; targeted mutation 1, John Lowe

Associated Genotypes

Allelic Composition	Genetic Background
Gfus^tm1Jbl/Gfus^tm1Jbl	involves: 129S2/SvPas * C57BL/6J