Phenotype Image Detail

Image

Caption

Analysis of placenta. A-D: DAPI-stained sections of placentae from E10.5 wild-type (A and C) and Mfn2^tm1Dcc/Mfn2^tm1Dcc (B and D) littermate embryos. The boxed areas of A and B are enlarged in C and D. Arrows and arrowheads indicate trophoblast giant cells. Note that the giant cells in D are sparser and have smaller nuclei. E and F: Hematoxylin-eosin stained sections from the placentae above. G and H: PL-I (giant cell marker) RNA in situ analysis of placentae from E9.5 wild-type (G) and mutant (H) littermates.

Copyright

This image is from Chen H, J Cell Biol 2003 Jan 21;160(2):189-200, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:81438

Associated Alleles

Symbol	Name
Mfn2^tm1Dcc	mitofusin 2; targeted mutation 1, David C Chan

Associated Genotypes

Allelic Composition	Genetic Background
Mfn2^tm1Dcc/Mfn2^tm1Dcc	involves: 129S/SvEv