Phenotype Image Detail

Image

Caption

Histological and echocardiographic analysis of hearts from adult Hbegf^tm2Mek/Hbegf^tm2Mek (uc/uc) mice. A and B: Hematoxylin and eosin staining of transverse sections through hearts of 12 week old mice at the papillary muscle level. Bar, 3 mm. C and D: High magnification pictures. Sections were stained with Azan-Mallory. Massive fibrosis (blue stain) is present in 12 week old Hbegf^tm2Mek/Hbegf^tm2Mek heart throughout the vessel wall. Bar, 250 um. E and F: Echocardiographic analyses of hearts from wild-type (+/+) and mutant mice. E: Representative images of M-mode analyses are shown. Arrows indicate end-diastolic (d) and end-systolic (s) dimensions, respectively. F: Physiological parameters of wild-type versus mutant hearts in 12 week old mice. HR, heart rate, sBP and dBP, systolic and diastolic blood pressure; LVDd and LVDs, left ventricular end diastolic and end systolic internal dimensions; FS, percent fractional shortening calculated as [(LVDd-LVDs)/LVDd] x 100. All values +/- SEM.

Copyright

This image is from Yamazaki S, J Cell Biol 2003 Nov 10;163(3):469-75, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:86547

Associated Alleles

Symbol	Name
Hbegf^tm2Mek	heparin-binding EGF-like growth factor; targeted mutation 2, Eisuke Mekada

Associated Genotypes

Allelic Composition	Genetic Background
Hbegf^tm2Mek/Hbegf^tm2Mek	involves: 129/Sv * C57BL/6 * CBA