Phenotype Image Detail

Image

Caption

Light micrographs of semithin (1 um) resin sections of murine paw skin showing epidermal changes in Krt10^tm1Tmm/Krt10⁺ (b) and Krt10^tm1Tmm/Krt10^tm1Tmm (c) mice in comparison to normal ridged skin (a) of wild-type mice. (a) Ridged epidermis comprises of 6-8 nucleated cell layers and a thin orthokeratotic stratum corneum. Epidermal buds are indicative of forming eccrine glands. (b) Lesional ridged skin is slightly acanthotic and hyperkeratotic with signs of incomplete cornification in places. (c) Perilesional ridged epidermis is markedly acanthotic and hyperkeratotic. Numerous suprabasal cells contain granular or fibrillar material. All, Richardson stain. Bars, 20 um.

Copyright

This image is from Porter RM, J Cell Biol 1996 Mar;132(5):925-36, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:31853

Associated Alleles

Symbol	Name
Krt10^tm1Tmm	keratin 10; targeted mutation 1, Thomas M Magin

Associated Genotypes

Allelic Composition	Genetic Background
Krt10^tm1Tmm/Krt10^tm1Tmm	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Krt10^tm1Tmm/Krt10^+	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)