Phenotype Image Detail

Image

Caption

Transmission electron micrographs of longitudinally sectioned collagen fibrils from wild-type (D) and Dcn^tm1Ioz/Dcn^tm1Ioz (E) tendon, after fixation in the presence of 0.05% cuprolinic blue and 0.3 M magnesium chloride, and staining with uranyl acetate to visualize the collagen binding pattern. Notice that the typical, 67-nm periodicity of the type I collagen is maintained in the mutant mice (E). However, numerous d bands are not occupied by proteoglycan granules (E, spaces between arrowheads and unfilled arrowheads), in contrast with the wild-type where nearly every d band is occupied (D). Bar 0.2 um.

Copyright

This image is from Danielson KG, J Cell Biol 1997 Feb 10;136(3):729-43, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:39212

Associated Alleles

Symbol	Name
Dcn^tm1Ioz	decorin; targeted mutation 1, Renato V Iozzo

Associated Genotypes

Allelic Composition	Genetic Background
Dcn^tm1Ioz/Dcn^tm1Ioz	involves: 129S1/Sv * 129X1/SvJ * Black Swiss