Phenotype Image Detail

Image

Caption

TEM of diaphragm muscle. Micrographs of longitudinal sections of diaphragm muscle from wild-type (A,C and E) and Neb^tm1(cre)Chen/Neb^tm1(cre)Chen mice (B,D,F,G and H) at embryonic day (E) 18.5 (A and B), postnatal day (PN) 1 (C and D), and PN 9 (E-H). In the noncontracting diaphragm at E 18.5, mutant mice showed normal sarcomeric organization with well-aligned sarcomeres (B) and were comparable with wild-type muscle (A). At PN 1, mutant mice exhibited misaligned sarcomeres with moderately wider Z-lines compared with wild-type (C and D). By PN 9, myofibril architecture was severely disrupted (F-H) with either thick (arrowheads in F), punctate (arrows in F-H), or dissolving Z-lines (G and H). In addition, M-lines became poorly defined, and abnormal accumulations of mitochondria were present. Bars, 500 nm.

Copyright

This image is from Bang ML, J Cell Biol 2006 Jun 19;173(6):905-16, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111470

Associated Alleles

Symbol	Name
Neb^tm1(cre)Chen	nebulin; targeted mutation 1, Ju Chen

Associated Genotypes

Allelic Composition	Genetic Background
Neb^tm1(cre)Chen/Neb^tm1(cre)Chen	involves: 129S1/Sv * 129X1/SvJ * Black Swiss