Phenotype Image Detail

Image

Caption

Ttn^tm1.1Her/Ttn^tm1.1Her embryos develop normally up to E9.0, followed by a failure to thrive. A: The wild-type (WT) and Ttn^tm1.1Her/Ttn^tm1.1Her (KO) embryos at E9.0 (a and b) develop normally with appropriate cardiac size and function. The mutant embryo at E10.0 (d) appears normal, including normal cardiac morphology, but is small for its age. At E11.0, embryonic and cardiac development of the mutant is delayed with reduced body size and pericardial hemorrhage (f). Arrows point to the heart. B: Histological analysis demonstrates normal development of the left ventricle and myocardium until E9.0. At E10.0, proper looping takes place, but ventricular wall thickness and trabeculation are reduced compared with wild-type mice. At E11.0, the difference in wall thickness becomes more prominent and is accompanied by cellular infiltration of the mutant pericardium (f, arrowheads). A, atrium; LA, left atrium; RA, right atrium; V, ventricle; M, myocardium; T, trabeculation. Bars, 500 um.

Copyright

This image is from Weinert S, J Cell Biol 2006 May 22;173(4):559-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111284

Associated Alleles

Symbol	Name
Ttn^tm1.1Her	titin; targeted mutation 1.1, Joachim Herz

Associated Genotypes

Allelic Composition	Genetic Background
Ttn^tm1.1Her/Ttn^tm1.1Her	involves: 129S4/SvJae * 129T2/SvEms