Phenotype Image Detail

Image

Caption

Histological analysis of the testes. The testis sections of control and Npc1^m1N/Npc1^m1N (Npc1^-/-) mice were stained with hematoxylin and eosin (original magnification, 35x). A: Normal spermatogenesis in control mice. B: Some tubules in mutant mice showed abnormal spermatogenesis while others appeared normal. Arrow 1 indicates fused spermatogenic cells with more than one nucleus; arrow 2 shows a degenerating seminiferous tubule. The tubule (arrow 3) in the lower right corner illustrates a region of apparently normal sperm production.

Copyright

This image is from Fan J, Mol Reprod Dev 2006 Oct;73(10):1284-91, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:119302

Associated Alleles

Symbol	Name
Npc1^m1N	NPC intracellular cholesterol transporter 1; Niemann Pick type C1 NIH

Associated Genotypes

Allelic Composition	Genetic Background
Npc1^m1N/Npc1^m1N	involves: BALB/c