Phenotype Image Detail

Image

Caption

Electron micrographs of sperm within the cauda epididymidis of 12 month old wild-type (inset) and Fshr^tm1Saco/Fshr^tm1Saco (FORKO, A-E) mice. In wild-type mice (A inset), the sperm head appears smooth and tubular or elongated in profile and cytoplasm enveloping the head is attenuated with no prominent organelles; the chromatin is condensed within the nucleus (N) and the acrosome (A) is closely applied to it (inset). Cytoplasm surrounding sperm tails (T) reveals the presence of a single axoneme and associated structures. In mutant mice, the nucleus (N) is often distorted or lobulated (A,B,E). The acrosome (A) shows a peeling off configuration (B,C). In mutant mice (B-E), the cytoplasm surrounding the head is prominent and contains vacuoles (V), membranous profiles (curved arrow), mitochondria (open stars), and several cross sectional profiles of tails (T), none of which are encountered in wild-type mice. Tails of sperm show a central axoneme, outer dense fibers and enveloping mitochondria (small arrowheads). Some sperm heads (E) are associated with a moderately dense amorphous material (dense stars). In the lumen of mutant mice (D), some cross sections of tails (T) show a double axoneme and associated structures enveloped by a commom cytoplasm. Original magnification: Inset, 10,465x; (A) 28,175x; (B) 35,525x; (C) 14,950x; (D) 9,315x; (E) 15,180x.

Copyright

This image is from Grover A, Mol Reprod Dev 2005 Oct;72(2):135-44, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:137005

Associated Alleles

Symbol	Name
Fshr^tm1Saco	follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi

Associated Genotypes

Allelic Composition	Genetic Background
Fshr^tm1Saco/Fshr^tm1Saco	involves: 129