Phenotype Image Detail

Image

Caption

Histologic sections of yolk sac visceral endoderm from wild-type and Apob^tm3Sgy/Apob^tm3Sgy embryos. Embryos were dissected in PBS. Portions of the yolk sac membranes were removed for genotype analysis by Southern blotting, and the remainder was fixed in 4% paraformaldehyde. Fixed embryos were embedded in paraffin and sectioned using standard techniques; sections were stained with hematoxylin and eosin. Sections from wild-type (+/+, A) and Apob^tm3Sgy/Apob^tm3Sgy (-/-, B) yolk sacs are shown. A layer of yolk sac visceral endodermal cells is visible overlying the embryonic mesoderm and blood islands, with the apical surface of these cells facing the maternal tissues. The arrows indicate vacuoles at the basal aspect of the visceral endodermal cells in the mutant yolk sacs. Magnification, 200x.

Copyright

This image is from Farese RV Jr, J Lipid Res 1996 Feb;37(2):347-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:84977

Associated Alleles

Symbol	Name
Apob^tm3Sgy	apolipoprotein B; targeted mutation 3, Stephen G Young

Associated Genotypes

Allelic Composition	Genetic Background
Apob^tm3Sgy/Apob^tm3Sgy	involves: 129S7/SvEvBrd * C57BL/6